Trial Results Suggest Longer Mesothelioma Survival Possible with New VEGF-Inhibitor, According to Surviving Mesothelioma

The Impact of Nintedanib on Mesothelioma Outcomes

Nintedanib and Chemotherapy Appear to Boost Mesothelioma Survival

Benefit was evident in epithelioid histology, with a median overall survival gain of 5.4 months...

Scientists studying the VEGF-inhibitor nintedanib (Ofev) say it improved the outcomes of mesothelioma patients on chemotherapy better than a placebo. Surviving Mesothelioma has all the details. Click here to read to full article.

In a newly published clinical trial sponsored by drug maker Boehringer Ingelheim, researchers gave nintedanib or a placebo drug along with standard mesothelioma chemotherapy to 87 patients for up to six 21-day cycles, then as a monotherapy after that.

“Benefit was evident in epithelioid histology, with a median overall survival gain of 5.4 months and median progression free survival gain of 4 months,” reports lead researcher Federica Grosso.

The report in the latest issue of the Journal of Clinical Oncology found that the number of mesothelioma patients who stopped taking nintedanib because of side effects was less than half of the number who discontinued the placebo.

“We are always encouraged by reports of a drug that could potentially boost the effectiveness of chemotherapy for patients with malignant pleural mesothelioma, especially since current success rates with the standard regimen leave a lot of room for improvement,” says Alex Strauss, Managing Editor for Surviving Mesothelioma.

To read more about the new nintedanib trial, including how this drug works similarly to Keytruda, see New Chemotherapy Booster May Extend Mesothelioma Survival, now available on the Surviving Mesothelioma website.

Grosso, F, et al, “Nintedanib Plus Pemetrexed/Cisplatin in Patients With Malignant Pleural Mesothelioma: Phase II Results From the Randomized, Placebo-Controlled LUME-Meso Trial”, September 11, 2017, Journal of Clinical Oncology, Epub ahead of print,

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